Consider speaking with Underwood (if you haven't already). With the 380 there may be an advantage to +P Defender or moving to the Penetrator. For my 43. I chose +P Defender because Penetrator was too much penetration for my intended use but still went +P because I wanted more speed from the shorter barrel and it didn't sacrifice performance. Still stayed short of 18".
I was also considering the 42 and for that I was going to go XP because it didn't over penetrate beyond my comfort zone but did compensate for shorter barrel and a typically underperforming ammo.