They are very different guns for sure. As much as I like Glocks, I am a huge fan of the 1911 platform. My daily carry weapon is a Kimber CDP II Custom (5" full size). The ergonomics of the 1911 and the short and crisp single action trigger really make a big difference to me.
If you are considering a 1911, you need to be ready to spend serious money. They truly are one of those things in life where you get what you pay for, especially if you plan to trust it with your life. If budget is a concern, Glock is definately the way to go. They have a proven track record for reliability and you simply can not go wrong with them. If you can only choose one and are looking the best value, the Glock wins hands down everytime.