As long as the holster protects the trigger while carrying then yes. If it doesn't, then you need to get a new holster. Also, train, train, train and become comfortable carrying with one in the chamber. Do it around your house for a week or so to get used to it. If you're asking the question of whether or not you should carry with one in the chamber, that means you are uncomfortable with it for a reason and you should probably not carry that way in public. Just remember, keep your finger OFF the trigger until you're ready to fire, don't point the gun at anything you don't intend to kill or destroy, and be sure of what is behind your target and you'll be good to go.