I have two non-Glock 10mms and until recently carried a G29 most of the time. Recoil is definitely heavier than a .45, but it's not bad at all, at least in the right package. I have early onset arthritis in both hands, so the 29 got to be too much to handle and I sold it. The other two are full size guns and are still manageable for me.
All in all, it's been one of my favorite rounds. My 29SF was my favorite gun, period, and I hated having to sell it, but saw no point in having it sit in the safe for the rest of my life.